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5th International Conference on Natural Products for Health and Beauty

Suppression of IL-6 production by Euphorbia sarcostemmoides extract

Akihiro Aioi(Author)
SPTM R&D Australia、Eskitis Institute Griffith University
Ron Quinn, Ngoc Pham
Eskitis Institute Griffith University

< Abstract >

Interleukin (IL)-6 production is triggered by ultraviolet B irradiation. Elevation of blood concentration of IL-6 produces cutaneous inflammation as a local effect and anxiety and fatigue as systemic effects. IL-6 is one of the major targets in health and beauty industries. Here we show the effect of Euphorbia sarcostemmoides (ES) extracts on lipopolysaccharide-induced IL-6 production by using ELISA and real time PCR. Lactate dehydrogenase (LDH) assay, cell viability MTT assay and proliferation assay showed that Euphorbia sarcostemmoides dichloromethane extract (ESDM) has very slight cytotoxicity at 0.2 milligram equivalent (mge)/ml. At the same concentration, ESDM suppressed IL-6 almost completely at both protein level and mRNA level. The suppressive effect of ESDM showed dose-relation manner, giving an IC50 of 0.02 mge/ml. Furthermore, ES ethanol extract suppressed IL-6 production without cytotoxicity. The mechanism of the effect should be explored, but the results showed here suggest that Euphorbia sarcostemmoides can be a candidate for local anti-inflammatory agents and active ingredients for cosmetics.


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