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”Journal of Japanese Cosmetic Science Society” Thesis Submission

Suppressive effect of Arnica montana extract on mediators

Megumi Nishikawa(Author)
Septem Soken Co., Ltd.
Akihiro Aioi
Septem Soken Co., Ltd. 、School of Med, University of Queensland

< Abstract >

Interleukin (IL)-6 is a well-known participant in cutaneous local reactions such as inflammation, pigmentation and carcinogenesis. Interestingly, previous studies demonstrated that IL-6 is involved in the central nervous system as well as local reactions. To discover compounds which down-regulate IL-6 production, we have examined the suppressive effect of Arnica montana extract (AM) on IL-6 production from RAW264.7 macrophage-like cells stimulated with lipopolysaccharide (LPS). Consequently, the extract from AM native to Europe significantly suppressed IL-6 expression in both protein and mRNA levels, with dose-relation manner. Furthermore, the suppressive effect of AM on prostaglandin (PG) E2 production was detected by using ELISA, but mRNA expression of COX II, a key enzyme in PG synthesis was not down-regulated. On the other hand, AM reduced nitric oxide (NO) production, concomitant with suppressing mRNA expressions of iNOS, a type of NO synthase. Conversely, AM did not increase the release of lactate dehydrogenase (LDH) as a cytotoxicity index, within the concentration used in the experiment. Taken together, these results suggest that AM is useful as a cosmetic ingredient for UV protection because AM suppressed the mediators to be produced and released from keratinocytes by UV irradiation.


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