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Conference Presentations

127th Annual Meeting of the Pharmaceutical Society of Japan

Correlation between reactive oxygen scavenging activity
of medicinal plant extracts used in cosmetics and skin physiology

Masamichi Ishigami(Presenter), Masanori Okada[Poster Presentation]
R&D Laboratory, Septem Soken Co., Ltd.
Prof. Hiromu Sakurai
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University

< Abstract >

In recent years, researchers looking for cosmetic raw materials have increasingly reevaluated the dermatological application of herbal extracts that have been empirically used since the ancient times. We have selected from the earliest oriental pharmaceutical monograph, 20 types of oriental herbs that may offer potential cosmetic benefits. Extracts from these herbs were evaluated for the activity to remove reactive oxygen species, which have been shown to be strongly linked to physiological phenomena such as dermatitis, melanin-production, or aging. The results were examined for their correlations with the skin’s physiological phenomena.

The results confirmed that each of these 20 oriental herbal extracts exhibits its own characteristic reactive oxygen scavenging activity and lipoperoxidation inhibitory activity. In particular, herbs such as burnet or rosa multiflora fruit with a high level of peroxinitrite scavenging activity also exhibited a high level of scavenging activity for singlet oxygen and superoxide. Moreover, although studies in recent years are showing that nitric oxide (NO) plays a role in the UV-induced pigmentation, peroxinitrite, formed by a reaction between NO and superoxide anion, has also been suspected of involvement in the melanin-production.

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